{"id":4373,"date":"2014-10-01T10:13:43","date_gmt":"2014-09-30T23:43:43","guid":{"rendered":"http:\/\/leemakennels.com\/blog\/?p=4373"},"modified":"2021-08-02T17:47:18","modified_gmt":"2021-08-02T07:17:18","slug":"labs-and-goldens-goldens-get-cancer-better","status":"publish","type":"post","link":"http:\/\/leemakennels.com\/blog\/aboutblog\/labs-and-goldens-goldens-get-cancer-better\/","title":{"rendered":"Labs and Goldens: Goldens get cancer better"},"content":{"rendered":"<p><span style=\"float: left; padding: 5px;\"><a href=\"http:\/\/www.researchblogging.org\"><img decoding=\"async\" style=\"border: 0;\" src=\"http:\/\/www.researchblogging.org\/public\/citation_icons\/rb2_large_gray.png\" alt=\"ResearchBlogging.org\" \/><\/a><\/span><\/p>\n<p class=\"p1\"><a href=\"http:\/\/www.plosone.org\/article\/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0102241&amp;representation=PDF\">A recent study<\/a>, published in July this year, considered desexing in Labradors and Golden Retrievers and the long term health effects. This study doesn&#8217;t find anything revolutionary, but <a href=\"http:\/\/leemakennels.com\/blog\/tag\/desexing\/\">adds to the building body of evidence<\/a>\u00a0on the health impacts of desexing.<\/p>\n<p class=\"p1\">In the US, 83% of dogs are desexed, and often desexing is performed before 6 months of age. The popularity of this elective surgery has increased over the last 30 years. This is in contrast to many European countries, where animals are left intact.<\/p>\n<p class=\"p1\"><strong>This study<\/strong> considered\u00a01015 Golden Retrievers and 1500 Labrador Retrievers.\u00a0It used data on all Labs and Goldens admitted to a hospital between 2000 and 2012 (retrospective data).\u00a0It mirrors <a href=\"http:\/\/leemakennels.com\/blog\/research-dogs-and-politics\/golden-retrievers-cancer-if-you-do-cancer-if-you-dont\/\">a study on Goldens in 2013<\/a>, and came up with similar results (which makes sense as it used a similar data set).<\/p>\n<p class=\"p1\">Dogs in the study were split by breed, then split by neuter status and age\u00a0of neutering. So in each breed, there is a) desexed at &lt;6 months, b) desexed at 6-11 months, c) desexed at 1 year, d) desexed at 2-8 years, and e) entire. (Dogs desexed at over 8 years were excluded from the study.)<\/p>\n<p class=\"p1\">While the study looked at lots of conditions, in particular it considered: hip dysplasia, cranial cruciate ligament tear, hemangiosarcoma, mast cell tumor, and mammary cancer. At times, the study lumped together &#8216;joint disorders&#8217; and &#8216;cancers&#8217;, with the logic: Surely if we want to avoid any and all, not just one type of cancer or one type of joint disorder!<\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-4396\" src=\"http:\/\/leemakennels.com\/blog\/wp-content\/uploads\/2014\/10\/goldenphotoblog-200x300.jpg\" alt=\"goldenphotoblog\" width=\"340\" height=\"510\" srcset=\"http:\/\/leemakennels.com\/blog\/wp-content\/uploads\/2014\/10\/goldenphotoblog-200x300.jpg 200w, http:\/\/leemakennels.com\/blog\/wp-content\/uploads\/2014\/10\/goldenphotoblog.jpg 640w\" sizes=\"(max-width: 340px) 100vw, 340px\" \/><strong>On Joint Disorders<\/strong><\/p>\n<p class=\"p1\">In both goldens and labs, the incidence of joint disorders in intact dogs (male and females) was about 5%.<\/p>\n<p class=\"p1\"><em>Overall, though, it was found the earlier a dog was desexed, the greater the incidence of joint disorders.<\/em><\/p>\n<p class=\"p1\">In Labrador Retrievers, neutering at earlier than 6 months doubled (to 12.5% in males) the incidence of one or more joint disorder. Golden Retrievers faired even worse, with the same\u00a0neuter-group having 4-5 times (27%) the incidence of one or more joint disorder.<\/p>\n<p class=\"p1\">Basically, there was a sliding scale: Golden Retriever males\/females desexed at 6-11 months had a 14%\/13% incidence of joint disorders. Golden Retriever males desexed at 2-8 years had a 10% incidence of joint disorders. While figures for Labrador Retrievers were not as high, they had a similar trend.<\/p>\n<p class=\"p1\">So, it seems from these results, the longer a dog is left entire, the healthier their joints.<\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\"><strong>On Cancers<\/strong><\/p>\n<p class=\"p1\">While males in both breeds got off lightly when it came to neutering and cancer,\u00a0and female Labradors were not much different, female Golden Retrievers drew the short straw.<\/p>\n<p class=\"p1\">There seems to be a &#8216;protective effect&#8217; from gonadal hormones against cancers, especially in female golden retrievers.<\/p>\n<blockquote>\n<p class=\"p1\">The results reveal that neutering through 8 years of age [in female golden retrievers] increases the risk of acquiring at least one of the cancers at a level 3-4 times that of leaving the female dog intact.<\/p>\n<\/blockquote>\n<p class=\"p1\">Mast cell tumours didn&#8217;t occur in entire Golden Retriever bitches, but occurred at a rate of 6% in neutered bitches. Other cancers (lymphosarcoma, mast cell tumours, and hemangiosarcoma), in Golden Retrievers, also occurred more frequently in spayed than entire bitches.<\/p>\n<p class=\"p1\">Mammary cancers were only seen in Golden Retriever bitches (not in Labradors). 1.4% of intact female\u00a0goldens were diagnosed with mammary cancer. If the bitch was neutered between 2-8 years, the incidence was increased to 2%.<\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\"><strong>Pyometra!<\/strong><\/p>\n<p class=\"p1\">Exclamation because I haven&#8217;t seen consideration given to pyo&#8217; before in one of these studies. A good start!<\/p>\n<p class=\"p1\">In Golden Retrievers, the incidence of pyometra in intact females was 1.8%.<\/p>\n<p class=\"p1\">In Labrador Retrievers, the incidence of pyometra in intact females was &lt;4%.<\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\"><strong>Conclusions<\/strong><\/p>\n<p class=\"p1\">It&#8217;s interesting that, while the Golden Retriever and Labrador Retriever are similar in looks, function, and size, it&#8217;s interesting that they have such a marked difference in terms of their incidence of joint disorders and cancers.<\/p>\n<p class=\"p1\">For example, Goldens neutered at &lt;6 months had a 20-27% incidence of joint disorders, while Labradors neutered at &lt;6 months had a 11-12% incidence.<\/p>\n<blockquote>\n<p class=\"p1\">&#8230;for both breeds, neutering at the standard &lt;6mo. period markedly and significantly increased the occurrence of joint disorders, although the increase was worse in the Golden than the Labrador.<\/p>\n<\/blockquote>\n<p class=\"p1\">Again, it&#8217;s important to recognise this is only part of a\u00a0growing body of research looking at the long-term implications of desexing. We have had studies before that have suggested:<\/p>\n<ul>\n<li>Desexed Golden Retrievers are\u00a0two times more likely to experience joint disorders, and three times more likely to experience cancers, than their entire\u00a0counterparts. (<a href=\"http:\/\/leemakennels.com\/blog\/research-dogs-and-politics\/golden-retrievers-cancer-if-you-do-cancer-if-you-dont\/\">link<\/a>)<\/li>\n<li>In Vizslas, there is a higher incidence of cancer (mainly lymphosarcoma, hemangisoarcoma, and mast cell tumours) in desexed dogs than those intact. (<a href=\"http:\/\/leemakennels.com\/blog\/dog-biology\/dog-health\/desexing-its-bad-for-vizslas-too\/\">link<\/a>)<\/li>\n<li>Osteosarcoma is two times more common in neutered dogs relative to intact dogs.<\/li>\n<li>In Rottweilers, osteosarcoma was 3-4 times more likely to occur in rotties desexed before 1 year of age.<\/li>\n<li>Cardiac and splenic hemangiosarcoma has a four and two times (respectively) greater incidence in spayed than intact females.<\/li>\n<li>There is a higher incidence of lymphosarcoma in neutered females than intact.<\/li>\n<li>Prostate cancer is four times more common in neutered males as intact males.<\/li>\n<li>Cutaneous mast cell tumours are four times greater in incidence in spayed females than intact females.<\/li>\n<\/ul>\n<p class=\"p1\">One of the big arguments for desexing bitches is the fear of pyometra and mammary cancer in bitches.\u00a0This study adds to growing evidence that mammary cancer isn&#8217;t as prolific as first thought. If you have an entire golden retriever bitch, your likelihood of experiencing mammary cancer or pyometra is 2.2%. If you have an entire labrador retriever bitch, your likelihood of experiencing mammary cancer or\u00a0pyometra is less than 4%.<\/p>\n<p class=\"p1\">While many of the studies mentioned above are to do with cancers, there is evidence regarding the impacts of desexing on joints as well.<\/p>\n<blockquote>\n<p class=\"p1\">\u201cThe effects of neutering in the first year of a dog\u2019s life, especially in larger breeds, undoubtedly reflects the vulnerability joints to delayed closure of long-bone growth plates from gonadal hormone removal\u201d<\/p>\n<\/blockquote>\n<p class=\"p1\">Studies like this have implications for studies of cancers over all. It is useful for us to examine what dog breeds have which types of cancer, for future research purposes.<\/p>\n<p class=\"p1\">This study did not look at cognitive decline accelerated by neutering, but acknowledges that there is some evidence for this and it is a field for further study.<\/p>\n<p>&nbsp;<\/p>\n<p><em>The Study:<\/em><br \/>\n<span class=\"Z3988\" title=\"ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.jtitle=PLoS+ONE&amp;rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0102241&amp;rfr_id=info%3Asid%2Fresearchblogging.org&amp;rft.atitle=Long-Term+Health+Effects+of+Neutering+Dogs%3A+Comparison+of+Labrador+Retrievers+with+Golden+Retrievers&amp;rft.issn=1932-6203&amp;rft.date=2014&amp;rft.volume=9&amp;rft.issue=7&amp;rft.spage=0&amp;rft.epage=&amp;rft.artnum=http%3A%2F%2Fdx.plos.org%2F10.1371%2Fjournal.pone.0102241&amp;rft.au=Hart%2C+B.&amp;rft.au=Hart%2C+L.&amp;rft.au=Thigpen%2C+A.&amp;rft.au=Willits%2C+N.&amp;rfe_dat=bpr3.included=1;bpr3.tags=Biology\">Hart, B., Hart, L., Thigpen, A., &amp; Willits, N. (2014). Long-Term Health Effects of Neutering Dogs: Comparison of Labrador Retrievers with Golden Retrievers <span style=\"font-style: italic;\">PLoS ONE, 9<\/span> (7) DOI: <a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0102241\" rev=\"review\">10.1371\/journal.pone.0102241<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><em>Further reading:\u00a0<\/em><br \/><a href=\"http:\/\/skeptvet.com\/Blog\/2014\/07\/potential-risks-of-neutering-and-age-at-neutering-for-godlen-retrievers-and-labrador-retrievers\/\">Potential Risks of Neutering and Age at Neutering for Golden Retrievers and Labrador Retrievers<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study, published in July this year, considered desexing in Labradors and Golden Retrievers and the long term health effects. This study doesn&#8217;t find anything revolutionary, but adds to the building body of evidence\u00a0on the health impacts of desexing. In the US, 83% of dogs are desexed, and often desexing is performed before 6 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4373","post","type-post","status-publish","format-standard","hentry","category-aboutblog"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/posts\/4373"}],"collection":[{"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/comments?post=4373"}],"version-history":[{"count":23,"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/posts\/4373\/revisions"}],"predecessor-version":[{"id":4401,"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/posts\/4373\/revisions\/4401"}],"wp:attachment":[{"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/media?parent=4373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/categories?post=4373"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/leemakennels.com\/blog\/wp-json\/wp\/v2\/tags?post=4373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}